Since you control what dies, you get to destroy everything, or you could just use a little mini-board wipe to clean up some small things while leaving your Vein Ripper or whatever in play
At a minimum, every card you care about should go into a soft plastic sleeve, often called a "penny sleeve." For your more valuable pulls, like a Special Illustration Rare, consider double-sleeving for an extra layer of protection
Out of all the new Murders at Karlov Manor pre-cons, Deadly Disguise was the one that most appealed to me
The real mean interaction involves Displacer Kitten, whenever you cast a spell from the yard using Noctis, the Kitten blinks a permanent, which can be used to reset finality counters or draw extra cards to offset the life loss
Paying the life is often a pain, but its a huge indestructible god thats a sac outlet with a bit of removal
Its not hard to turn Expressive Iteration into a better version of draw two cards, which is practically unheard of at two mana