Your goal is to have the least impact you can on the game, but you have to remove a rule that has some effect on game play
I once played a game where I ignored an attack by Pharika, God of Affliction, Wingmate Roc, the bird token, Siege Rhino, and several 1/1 deathtouch snakes for several turns in a row by just (massively) outpacing it with lifegain
Foundation Breaker is another one to consider
So it's not that unbalanced in my experience, but the opportunity to draft a dud deck is greater than most other Standard sets
As for Standard, I played Damnation in my comeback tournament, Regionals 2007
Whether youre sleeving a new deck, organizing a collection, or creating custom cards, keeping these size specifications in mind is essential for enhancing your MTG experience.