There exist multiple decks playing Urzas Saga, the most popular being Affinity, Amulet Titan and Hammer Time, and Force of Vigor can regularly destroy two permanents for zero mana in these matchups
They work against mill in a similar fashion: Shuffling your library back into your deck against a mill deck is equivalent to resetting your life total to 20, 40, or whatever against a more standard Magic deck attacking your life total
Since it's not instant speed it's not reliable enough removal to use when you need it
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