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This may seem like it's not that productive, as your opponent will often die to regular damage first, but a lot of what makes poison counters special in Phyrexia: All Will Be One is the Corrupted mechanic, which is an ability word that turns on when your opponent has three or more poison counters

Sure, a three-mana 3/4 with reach is solid, and will likely outclass anything else your opponent is playing early on

Someday, I would like to play a dredge deck and understand it well

However, that high cost has a large payoff

Not sure what that is

It is more the case of whether the card disadvantage is worth the effect when you are not screwed or flooded, which the depth of filtering with a nice range of costs and the synergy of Looting with so many effects ensure is the case