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This IGF-1 LR3 vs PEG-MGF comparison breaks down the mechanism of action, half-life, and site of activity researchers weigh before selecting a research-grade IGF-1 LR3 for a given protocol
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Timing: Administered before meals or before bedtime
The "LR3" modification (a substitution at position 3 and an arginine extension) reduces IGF-1 LR3's affinity for IGF-binding proteins (IGFBPs)
The consequence that actually shows up on a bench is this: in a serum-containing medium, the free fraction of added IGF-1 LR3 is much higher than the free fraction of an equal mass of native IGF-1, and it is far less buffered, because the binding-protein reservoir that would normally absorb an excess and release it slowly is largely not engaging with this molecule
J Clin Neurosci
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