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When the body, especially after repeated administration, recognizes the originally inert PEG chains as foreign substances, specific anti-PEG antibodies will be produced [216]

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After OGD treatment, the number of Ki-67-positive endothelial cells significantly decreased, while the intracellular expression levels of senescence markers P21, P53, and the DNA damage indicator -H2AX were markedly elevated (Figure 3B)