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Efectos secundarios persistentes o graves : Aunque los efectos gastrointestinales leves son comunes al inicio del tratamiento, debe buscar atencin mdica si experimenta: Nuseas o vmitos severos que impiden la ingesta adecuada de alimentos o lquidos Dolor abdominal intenso y persistente, especialmente si se irradia a la espalda (posible pancreatitis) Dolor en el cuadrante superior derecho del abdomen, ictericia o fiebre (posible problema de vescula biliar) Signos de deshidratacin debido a vmitos o diarrea prolongados (que pueden aumentar el riesgo de lesin renal aguda) Cambios visuales o sntomas de retinopata diabtica Sntomas de hipoglucemia (mareos, sudoracin, confusin), especialmente si toma insulina o sulfonilureas concomitantemente Reacciones alrgicas graves como hinchazn facial o dificultad para respirar Situaciones especiales : Consulte inmediatamente con su mdico si est embarazada, planea quedar embarazada o est amamantando, ya que estos medicamentos no estn recomendados durante el embarazo o lactancia y deben suspenderse con anticipacin segn su vida media

and those tissues when have higher levels of histamine

Several factors influence the choice of needle and syringe: Type of injection : Intramuscular (IM) or subcutaneous (SC) Gauge of the needle : Diameter of the needle Length of the needle : Determines the depth of injection Volume of the syringe : Determines the amount of B12 to be injected 3

Research has examined its role in cell growth signalling and IGF-1 receptor activation

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