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Although the shown enhancement of POMC neuronal activity is likely to contribute to the observed increased weight loss with GLP-1GIPLani relative to GLP-1GIP, mechanisms in the hindbrain are also known to account for GLP-1-induced weight loss, and may thus also have a role in the increased weight loss induced by GLP-1GIPLani relative to GLP-1GIP
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On one hand, future clinical trials should incorporate mood outcomes as pre - specified endpoints and employ standardized measurement tools to avoid the low sensitivity resulting from reliance on self - reported adverse events
Lost productivity, inability to participate in recreational activities, and the frustration of multiple failed treatments contribute to decreased quality of life
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