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Specific metabolite subclasses were associated with asthma diagnosis (e.g., sphingosines, sphinganines, serotonin, indole-3-propionate), FEV 1 (e.g., ceramides, sphingomyelins, kynurenine), FVC (e.g., sphingomyelins, quinolinate), and asthma exacerbations (e.g., ceramides, methylobutyrate, isobutyrate)

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Acknowledgements We thank the 23andMe research participants and employees who made this study possible