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The SURMOUNT-5 trial in 2025 showed an average 20.2% body weight reduction, outperforming GLP-1-only medications in direct comparisons

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Regulatory Peptides 128: 87-91, 2005 [ Links ] 5

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Semaglutide mimics GLP-1, a hormone your gut naturally releases after eating

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Thats not because they failed. Its because hunger signaling often returns when the medication is removed, and the body tends to defend its prior weight

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