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SAM, in turn, provides methyl for the synthesis of DNA, fatty acids, phospholipids and proteins, with methylation of myelin proteins maintaining the stability of the myelin sheath

Common side effects include scalp irritation, dryness, and unwanted facial hair growth

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ATP on its own, and possibly modulated by these coupling factors, triggers closure of the ATP-sensitive potassium channel, resulting in membrane depolarisation that increases intracellular calcium to cause insulin secretion

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Up to 30% of individuals on metformin are considered to experience undesirable gastrointestinal side effects (Forslund et al., 2015)