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Additionally, GLP-1 receptors are expressed in parts of the brain involved in mood and the reward system, which could explain the reductions we observed in alcohol and substance use. GLP-1RAs as a preferred treatment for psoriasis The researchers found the benefits of GLP-1RAs were especially pronounced in psoriasis patients, compared with matched controls
Importantly, none of the currently available trials specifically target the early PsA window, which is increasingly recognized as a critical period for disease modification
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Compared to placebo, GLP-1 receptor agonists reduced the risk of kidney failure by 16% and the worsening of kidney function by 22% (defined by a drop in estimated glomerular filtration ratea measure of how much blood the kidneys filter clean every minuteof at least 50%)
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