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During this process, GPx uses reduced glutathione as a necessary cofactor to reduce dangerous hydrogen peroxide (HO) and lipid hydroperoxides into harmless water and alcohols

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These differences support a potentially complementary therapeutic strategy in patients with overlapping HF, metabolic, and atherosclerotic risk

And while the drugs safety profile appears to be in line with approved GLP-1 drugs, at least some people discontinued taking retatrutide due to the drugs adverse effects