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When it comes to people with obesity and without diabetes, the 2025 AACE guidelines recommend semaglutide and tirzepatide as first line over other drug classes for a variety of conditions, including those with prediabetes, type 2 diabetes, osteoarthritis, kidney disease, heart failure, fatty liver, cardiovascular protection, and sleep apnea
Other reported side effects include injection site reactions (pain, redness, swelling), low potassium levels (hypokalemia), and potential heart failure when combined with thiazolidinediones
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Comparative effectiveness of GLP-1 receptor agonists on glycaemic control and weight management: a systematic review and network meta-analysis
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these medications are not covered for weight loss
