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FGF23 is increased in individuals with AKI, and enhancement of FGF23 activates TGF- and Wnt/-catenin, promoting renal fibrosis and contributing to the transition from AKI to CKD [103, 104]
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Furthermore, the ELF GSH levels that are maintained may in fact be tied to the CS induced depletion of GSH and that the lung may utilize GSH originating from other sources such as the liver and plasma to generate the high levels of ELF GSH