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Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimers disease

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To establish a rigorous threshold for X(PC) sensitivity amidst the inherent variance of high-throughput pooled screening, we applied the following criteria: cell lines were classified as sensitive (hits) if they exhibited a significant ( P 0.5) yielded a signature of 84 genes significantly upregulated in sensitive lines (Extended Data Fig

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