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These cytokines can promote cognitive dysfunction as they are able to disrupt the blood-brain barrier (BBB), allowing proinflammatory cytokines (52), cells (such as dendritic, B cells, and T cells) (52), and gut microbes or toxins (355) to translocate into the brain and promote inflammation ( Figure 10 )
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Higher concentrations deliver powerful anti-inflammatory effects essential for managing severe tissue damage and acute inflammatory responses
Once injected, B12 enters the bloodstream directly without requiring stomach acid, intrinsic factor (a protein necessary for B12 absorption), or healthy intestinal function
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