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However, up to 89% of participants taking efinopegdutide experienced gastrointestinal adverse events (mostly nausea, vomiting and diarrhoea) relative to 28% taking placebo and 60% taking liraglutide ( SAR425899 (Sanofi) is another example of a GLP-1/glucagon co-agonist which has been tested in Phase 1 trials
References 1 RosenfeldRGBakkerB
Pending the results of the FOCUS Trial and other future studies, how should optometrists approach diabetic patients who go on a GLP-1/GIP agonist
The insulin receptor: both a prototypical and atypical receptor tyrosine kinase
One study of various in-use cosmetic items (lipsticks, mascaras, brushes) reported that up to 90% of products showed bacterial contamination, including Staphylococcus aureus, as well as fungi like Candida, among the most common contaminants
Gastrointestinal effects are the most frequently reported adverse reactions according to the SmPC, with specific frequencies from clinical trials including nausea (approximately 44%), diarrhoea (30%), vomiting (24%), and constipation (24%)
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