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Similar content being viewed by others Introduction Class B G protein-coupled receptors (GPCRs), whose endogenous ligands are peptide hormones, are key mediators of normal human physiology and serve as valuable drug targets for many diseases including diabetes, metabolic syndrome, osteoporosis, migraine, depression, and anxiety 1

NICE appraisals are based on robust clinical evidence, cost-effectiveness analysis, and post-marketing safety data standards that investigational peptides do not yet meet

Carnitine or L-b-hydroxy-c-N-trimethylaminobutyric acid is synthesized in the liver and kidneys

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