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A 2015 review in the Journal of Clinical Endocrinology confirming that GHRH analogs combined with ghrelin-pathway agonists produce a synergistic GH secretory response that exceeds additive effects when either compound is used alone provides the mechanistic basis for why combination therapy is the standard in supervised clinical settings

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One GLP-1RA, liraglutide, has been approved to treat obesity, and another, semaglutide, is in clinical trials

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