CPT 27458: unilateral femoral osteotomy with an externally controlled intramedullary lengthening device CPT 27713: unilateral tibial osteotomy with the same lengthening device CPT 99445: remote physiologic monitoring device supply for 2 to 15 days, useful for post-operative tracking CPT 99470: first 10 minutes of remote physiologic monitoring treatment management Revised Codes Sacroiliac joint arthrodesis coding was refined for the current surgical technique

The Drug Resistance Crisis Why New Options Matter Why We Urgently Need New Gonorrhea Medication Neisseria gonorrhoeae has earned its reputation as a superbug by systematically developing resistance to every antibiotic class introduced over the past century, making the December 2025 approval of zoliflodacin and gepotidacin a critical turning point in the battle against drug resistant gonorrhea. The Antibiotic Resistance Timeline 1940s: Penicillin became the first effective gonorrhea cure, providing near-100% success rates for two decades before widespread resistance emerged. 1970s-1980s: As penicillin resistance spread globally, healthcare providers shifted to tetracyclines and spectinomycin, only to see Neisseria gonorrhoeae treatment options narrow again within years. 1990s-2007: Fluoroquinolones like ciprofloxacin offered hope as oral gonorrhea antibiotics, but the CDC discontinued fluoroquinolone recommendations in 2007 after surveillance data revealed alarming resistance rates approaching 100% in some regions. 2010-present: Ceftriaxone injections combined with azithromycin became the last-resort standard for gonorrhea treatment, leaving virtually no backup options when resistance develops. The World Health Organization designated Neisseria gonorrhoeae as a high-priority pathogen in 2017 due to multidrug resistance affecting penicillin, tetracyclines, macrolides, sulphonamides, quinolones, and now emerging resistance to extended-spectrum cephalosporins

A simple alcohol consumption guideline is one standard drink an hour
The injection is typically given in a muscle, most commonly in the upper arm, thigh, or buttock
Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse diet-induced obesity in mice. Nature Medicine, 25(11), 17611771
The lead author of the 2025 narrative review titled "Regeneration or Risk?" emphasized the urgent need for randomized controlled trials