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PAPS is a universal donor of sulfonate moiety in sulfonation reactions and has been shown to by synthesized by almost all tissues in mammals from inorganic sulfate (Klaassen & Boles, 1997)

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However, gastrointestinal side effects (constipation, nausea/vomiting, flatulence, diarrhea, and taste alteration) occurred in 9/15 (60%) patients in both groups (21 incidents in SFN and 17 in the placebo) (30)

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