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Independent of cell type, after glucose entry, glucose is first phosphorylated by hexokinase (EC 2.7.1.1) producing glucose 6-phosphate
Iron overload in thalassemia acts as a redox-active center and there is resultant increase in the production of free radicals [159]
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52 Consequently, a novel regulation mode of lactylation using lactate as a direct donor without necessitating the formation of lactyl-CoA is proposed, expanding the substrate range of lactylation
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