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Up to now, powerful genetic tools allowed clarification of the significance, dispensability and potential of cystine transporters for ferroptotic cell death in PDAC and breast cancer ( via xCT ( A high extracellular glutamate concentration was one of the first xCT inhibitors described but a few years later, erastin (standing for eradicator of RAS and small T antigen-expressing cells) was identified by Stockwell's group in RAS-mutated cancer cell lines as inhibitor of xCT transport ( in vitro studies as efficient inducer of ferroptosis in many different cancer types, including breast, PDAC, lymphoma, renal, brain and ovarian cancers ( via transsulfuration pathway is a potential resistance mechanism under cysteine depletion conditions

10.1111/j.1364-3703.2009.00558.x 181 ZhaoJ.WangJ.AnL.DoergeR

doi: 10.3390/ijms25179302 167 Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment (COC)

Lee SY, Kim TH, Choi WG, Chung YH, Ko SG, Cheon C, et al