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On the plus side, semaglutide may help protect your heart when you have diabetes or obesity

Ozempic (semaglutide) slows gastric emptying and reduces gastrointestinal motility as part of its mechanism of action, which can decrease bowel movement frequency and cause constipation in 1-10% of users

These medications work, but they arent free, they require weekly injections, and the headlines about rebound weight gain are hard to ignore

This is why patients who never experienced cramps before starting a GLP-1 suddenly develop them during the first 4-8 weeks of dose titration, when GI side effects peak

Rodriguez says

These heart benefits showed up whatever amount of weight people lost