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As with all medications, semaglutide can cause side effects that impact the gastrointestinal system which can lead to nausea, or feeling sick

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The evaluated GLP-1RAs were semaglutide (IC 025 = 2.13), liraglutide (IC 025 = 1.18), dulaglutide (IC 025 = 3.76), exenatide (IC 025 = 3.52), and albiglutide (IC 025 = 3.91), none of which exhibited a signal of disproportionate reporting

It was approved by the EU in 2014 and by the FDA in 2019 for this purpose

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GLP-1 medications also have the potential to worsen reflux, increase constipation, and, sometimes, cause diarrhea