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Conversely, in rats the distal ileum and in pigs the caecum are the anatomical regions with the highest amounts of GLP-1 ( + cell densities, indicating a possible translational resistance ( Figure 1 The L-cells derived cocktail of hormones is believed to play pivotal roles in digestion, for example slowing down the GI motility (PYY) and suppressing the appetite in vivo (GLP-1, oxyntomodulin, PYY), apparently in response to direct sensing of the gut luminal content via G-protein coupled receptors or through neuronal circuits ( Current in vitro technologies are not capable to support for long-term ex vivo the growth of isolated GLP-1 producing-cells

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Urinary urgency is also extremely common (84% of the same population), 46 but urgency is considered a characteristic symptom of OAB and can confound the diagnosis

Time it carefully

Theyre also separate models