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Some studies have found that these side effects are most common during the first eight to 12 weeks of treatment
reported in approximately 4060% of participants in higher-dose groups [1] Vomiting reported in approximately 2030% of participants at higher doses Diarrhoea Constipation Decreased appetite (which, whilst contributing to weight loss, can also be uncomfortable) The majority of gastrointestinal events were mild to moderate in severity and tended to diminish over time as participants adjusted to the medication
The practical point is that this behaves like other chronic conditions: stop treating diabetes, hypertension, or high cholesterol, and they return too
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