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Whereas occludin and junction adhesion molecule have a regulatory role, claudins are transmembrane proteins mainly responsible for the intestinal barrier function

It possesses various pharmacological activities, including neuroprotective effects [96], immune regulation [56], gut microbiota regulation [137], and as an antioxidant [80]

Cancer-related fatigue A systematic review and meta-analysis by Marx (2017) evaluating the efficacy of L-carnitine supplementation for the treatment of cancer-related fatigue included three RCTs (Hershman 2013, Cruciani 2012/2018, Kraft 2012)

FIGURE 5 TABLE 1 Protective effect of polyphenols against cisplatin-induced ototoxicity

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