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This is where GLP-1 quietly changes the entire equation
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Patients should never accelerate the titration schedule without medical guidance, as this may worsen side effects without improving therapeutic outcomes
Tirzepatide appears to be one of them
Our findings revealed EC 50 values of 3.97 nM and 2.43 nM for GLP-1R internalization mediated by GEP44 and Ex-4, respectively, and EC 50 s of 1.59 nM and 7.13 nM for GEP44 and Ex-4, respectively, for -arrestin-2 recruitment
doi:10.1038/288715a0
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