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In vivo and in vitro models, it was found that in the IDH1 mutant glioma cells intervened by triptolide, the transcriptional activity of Nrf2 was suppressed, and the expression of genes related to glutathione anabolic metabolism (GCLC, GCLM, and SLC7A11) was significantly down-regulated

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Bacteriostatic water is stored at room temperature, away from direct light, and does not require refrigeration prior to opening

Despite the challenges posed by the limited signal-to-noise ratio of fMRI in deep brain nuclei, advances in imaging sequences 82,83,84 , ultra-high field MRI 85,86,87 and optimized processing methods 88,89,90,91,92 will further enhance the feasibility of this approach