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Scientific references National Center for Biotechnology Information

Because these medications affect the way the body digests food, they can also cause disruptive gastrointestinal side effects, including a loss of appetite, stomach upset, nausea, vomiting, or diarrhea

Effect of propranolol on serum-melatonin [PMID: 69926] Laboratory literature summary: Effect of propranolol on serum-melatonin

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Additionally, explains, Vidmar, Topiramate provided minimal appetite suppression for her, which is consistent with what we sometimes see, its effects are modest, and individual response varies widely

Using them together may intensify digestive symptoms and reduce medication tolerance