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A prospective pilot study run in 2004 involved 18 non-diabetic patients with biopsy-proven NASH and tested hepatic histological improvement as the primary outcome after a 48-week course of pioglitazone: the results showed significant improvement in histology regarding all major features of NASH (steatosis, parenchymal inflammation, cellular injury, and Mallory bodies) including fibrosis, despite a significant increase in body weight [59]

32301250 to B.Z.), ShanghaiTech University, Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine at ShanghaiTech University (to W.S