In the Phase 2 retatrutide trial ( Jastreboff et al., NEJM 2023 ), body-composition imaging showed fat mass falling substantially more than lean mass, meaning the majority of the weight lost was fat
Qsymia is used in combination with recommendations for diet and physical activity to achieve weight loss in obese individuals at least 12 years old and in overweight adults with at least one weight-related comorbidity
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doi: 10.1056/NEJMoa2307563