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Taken together, the reaction scheme described in Fig
The peptide sequence incorporates critical modifications to native human amylin: an N-terminal lipidation with eicosanedioic acid conjugated through a gamma-glutamic acid linker, strategic proline substitutions to prevent fibril formation, and an amidated C-terminus to enhance receptor binding
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The peptide sequence (residues 110128) was D-P-V-G-S-P-T-S-G-A-S-L-N-G-T-P-F-K-K-K, with an additional lysine added for charge
Abstract CagriSema is a combination of amylin (cagrilintide) and glucagon-like peptide-1 (semaglutide) analogues being developed for weight management
Glutathione S-transferase in mucus of rat small intestine [PMID: 10746931] Laboratory literature summary: Glutathione S-transferase in mucus of rat small intestine
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