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Understanding where this sequence sits within the larger formula helps researchers appreciate what portions of the molecule are most important for activity

Importantly, BefA-mediated effects are independent of inflammatory cascades: administration of purified BefA or conditioned media enriched in BefA does not elevate pro-inflammatory cytokines and does not activate NF-B, JNK, or STAT1 signaling

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Moreover, chemical or genetic manipulation of GSH pool stimulated mitophagy but not general ATG

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