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It should only be used for up to 48 hours without medical advice
You can start to experience some appetite suppression
Compound Receptors Peak trial weight loss Lean mass as share of loss Semaglutide (Ozempic/Wegovy) GLP-1 ~14.9% (STEP-1, 68 wk) ~39% Tirzepatide (Mounjaro/Zepbound) GLP-1 + GIP ~20.9% (SURMOUNT-1, 72 wk) ~25-40% Retatrutide GLP-1 + GIP + GCGR ~24.2% (Phase 2, 48 wk) Comparable class range Best for understanding the takeaway: the percentage of loss that is lean mass is roughly constant across the class
Moiz A, Filion KB, Tsoukas MA, Yu OH, Peters TM, Eisenberg MJ
When plateaus typically start The timing depends on your medication: Semaglutide (Ozempic, Wegovy): Plateaus typically occur at 6 to 12 months, with average total weight loss of 15 to 20 percent of starting body weight
Statistical analysis was rigorously designed to assess treatment efficacy and account for missing or incomplete data
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