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While X(GD_Sh2)cs exact cleavage site remains unconfirmed, both this P1 proline and P12 arginine are established substrate positions for the later X(GD_L)f and X(GD) variants

Individuals with this variant may have higher homocysteine levels and an increased risk of certain conditions, particularly when B vitamin status is inadequate

no large phase 3 trials have been completed, and the compound is not approved for any clinical use

NAT1 has also been detected in cancer cells, in which it may not only play a role in the development of cancers through enhanced mutagenesis but may also contribute to the resistance of some cancers to cytotoxic drugs (Adam et al., 2003)

Neurosci Biobehav Rev 114:134155 Zhang L, Huang J, Zhang Z, Cao Z (2021) Altered metabolites in the occipital lobe in migraine without aura during the attack and the interictal period

Retrospect on the research of the cultivation of Gastrodia elata Bl, a rare traditional Chinese medicine