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Insulin has also been suggested to play a significant role as a paracrine regulator of glucagon secretion (the intra-islet hypothesis), although the mechanism by which this inhibition occurs is not well elucidated (133)

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104 Recent studies revealed that in macrophages, the mediator binds to 2-ketoacid dehydrogenases, generating acetyl-CoA, which increases histone acetylation levels in specific chromatin regions, thereby regulating gene transcription

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