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Endnotes: The efficacy estimand represents efficacy had all randomized participants remained on study intervention (with possible dose interruptions and modifications) without initiating prohibited weight management treatments (and glycemic rescue therapy for glycemic endpoints only)

4 Epidemiological evidence supporting the benefits of DPP4i in preventing AD In addition to the experimental evidence presented both in vitro and in vivo , accumulative evidence from clinical studies have supported the neuroprotective effects of DPP4i in AD (Table 1)