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R., Kazemi, K
Figure 1 The biological effects of testosterone are mediated both by direct binding and activation of the androgen receptor, as well as indirectly through its metabolic conversion to biologically active derivatives, including 5-dihydrotestosterone (DHT) via 5-reductase and oestradiol via aromatization, which subsequently act through androgen and oestrogen receptors (ER/ER), respectively
Psychiatry 13:17
Second, "cleared from plasma" is not "gone." Metabolites, downstream biomarkers, and receptor-level effects can persist long after the parent compound has fallen below the limit of quantification, which is the single most misunderstood point in this whole topic
Two of the most discussed molecules in modern wellness are NAD+ and glutathione
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