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Both the GIPR and GLP1R are expressed in the central nervous system, wherein receptor activation produces anorectic effects enabling weight loss

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Additionally, a pilot randomized trial reported that short-term combination treatment with beinaglutide and metformin was more effective than metformin monotherapy in lowering body weight, improving insulin sensitivity, and reducing androgen excess in women living with PCOS and obesity [33]

Patients in the retatrutide trial taking 4mg, 9mg, and 12mg doses lost an average of 19%, 26%, and 29% of their starting weight, respectively

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