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The net result of the PPP, if not used solely for R5P production, is the oxidation of G6P, a six-carbon sugar, into a five-carbon sugar

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Here is what participants achieved on average: Mounjaro (tirzepatide 15mg) SURMOUNT-1: Week 4: approximately 2 to 3% body weight loss Week 12: approximately 7 to 8% Week 24: approximately 13 to 15% Week 52: approximately 18 to 20% Week 72 (end of trial): average 20.9% Wegovy (semaglutide 2.4mg) STEP 1: Week 4: approximately 1 to 2% body weight loss Week 12: approximately 5 to 6% Week 24: approximately 9 to 10% Week 52: approximately 12 to 14% Week 68 (end of trial): average 14.9% These are averages

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At the same time, payers are quietly rebelling: benefit budgets are strained, employers are pulling coverage, and policymakers are questioning how to sustain access to drugs that may be lifelong therapies for millions