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Additionally, semaglutide has been observed to slow down gastric emptying, which contributes to prolonged sensations of fullness and further aids in reducing overall caloric intake
[14] [1] Naltrexone blocks opioid receptors, interrupting the autoinhibitory feedback loop on POMC neurones and reducing the rewarding aspects of eating particularly the pleasure derived from highly palatable, calorie-dense foods via mesolimbic reward pathways
Thomsen, M
Human data barely exists
, Scitec
This can be OK for some people who may respond well and not need a more potent drug, or those with less body fat to lose
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