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[138], performed an in vitro study in cardiomyoblasts showing that pretreatment with EPA or DHA increased UCP2 expression, which promotes mild mitochondrial uncoupling and reduces oxidative stress
An Bras Dermatol
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However, as different nuclear receptors have evolved to bind hydrophobic LxxLL consensus motifs through similar binding mechanisms, it remains important that mimetics are designed in a way that conveys greater selectivity to the AR
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