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These include: Nausea (affecting 20-40% of patients initially) Vomiting Diarrhoea Constipation Abdominal discomfort These effects typically arise from delayed gastric emptying and direct effects on the gastrointestinal tract
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When the continuing annual HbA1c drift reached 9%, it was assumed that use of bolus insulin would be able to maintain HbA1c level and modelled to remain at that level throughout the models remaining time horizon
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