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Chemical and instrumental approaches to treat hyperpigmentation

Efficacy of orgotein in prevention of late side effects of pelvic irradiation : a randomized study

337 The MSU crystals are initially engulfed by macrophages, which then facilitate the assembly and activation of the NLRP3 inflammasome, preceded by priming through pathways that activate NF-B, such as those initiated by the engagement of Toll-like receptors (TLRs) within the TLR family

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Some studies that do exist show positive outcomes, while others have been less conclusive

Shimazaki T, Kaku A, Chaki S (2010)