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It was just a research project
This beneficial effect is evident in the G protein-biased agonist Exendin-phe1, derived from a single phenylalanine substitution at position 1 in Exenatide, which displays improved receptor recycling, reduced receptor desensitization, and sustained incretin-stimulated insulin secretion ( Genetic variation at the incretin receptors The most direct answer to why people fail to respond to incretin therapies is that they might express non-functional incretin receptors
Martin-Cortazar C, Chiodo Y, Jimenez RP, Bernabe M, Cayuela ML, Iglesias T, et al
As lixisenatide is known to delay gastric emptying [14], a marked decrease in postprandial hyperglycemia was noted with lixisenatide [57,58], which is a characteristic property of the short-acting GLP-1 analogs [30]
Furthermore, information on GLP-1 receptor expression in the heart is still lacking, and whether GLP-1RAs act directly or indirectly on the cardiovascular system remains inconclusive
