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Sixteen studies were included in the quantitative synthesis, comprising a total of 6,098 participants

Some disorders of intracellular cobalamin metabolism (cblC, cblD-MMA/Hcy, cblF, and cblJ) do not only compromise the synthesis of methylcobalamin, but also the synthesis of adenosylcobalamin, cofactor of the enzyme methylmalonyl-CoA mutase, leading to elevated concentrations of both tHcy and methylmalonic acid (MMA)

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While B12 injections are generally safe, side effects like redness, swelling, or pain can occur

Its effectiveness also extends to improved insulin secretion and reduced glucagon levels