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Sometimes unexplained worsening of symptoms can be seen after having been administered several supplementations, even as long as weeks later

[121] Age is also a contributing factor: elderly individuals are often achlorhydric due to reduced parietal cell function in the stomach, increasing their risk of vitamin B 12 deficiency

Journal of pharmacological sciences , 108 (1), 7-17

These studies suggest that alterations in various brain regions can contribute to AD-associated aggressive behavior

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